#22 The Next Generation Study: In-utero exposures and breastfeeding initiation after birth for Indigenous children exposed to pre-gestational diabetes.
Camille Glidden, University of Manitoba; Brandy Wicklow, University of Manitoba; Farrah Jabar, Children’s Hospital Research Institute of Manitoba; Sarah Colatruglio, Children’s Hospital Research Institute of Manitoba
The Next Generation Study is a longitudinal birth cohort study examining risk factors for the development of type 2 diabetes in Indigenous children. In-utero exposure to pre-gestational diabetes is known to increase the risk of type 2 diabetes development in children. In previous studies, breastfeeding for at least 12 months was shown to reduce the risk of type 2 diabetes development in children born to Indigenous mothers with pre-gestational diabetes.
Data was collected through medical chart review of mothers during pregnancy and at delivery. Descriptive statistics were performed on the dataset.
Within the cohort of 270 offspring, charts with a complete dataset were collected for 102 offspring and their mothers. Median maternal age at delivery was 22.0 years (15.2-35.1 years) and the median maternal pre-pregnancy BMI was 27.95 kg/m2 (18.0-41.90 kg/m2). The rate of smoking during pregnancy was 61.8% and the rate of alcohol and drug use was 12.7& and 10.8%, respectively. C-sections were performed for 44.1% of all births. In infants, the median gestational age was 37 weeks (31-40 weeks), with 34.3% of infants born preterm (<37 weeks). 1.96% were small for gestational age, 58.82% were average for gestational age, and 39.22% were large for gestational age. Finally, the rate of breastfeeding initiation for the offspring was 47.1%.
Infants in this cohort are exposed to above average rates of smoking, preterm birth and birth by c-section. Additionally, these infants have a low rate of breastfeeding initiation, which could be a protective factor against the development of diabetes.