#21 Vitamin D Status in Indigenous Youth with Type 2 Diabetes
Melissa Gabbs, Children’s Hospital Research Institute of Manitoba; Allison Dart, Children’s Hospital Research Institute of Manitoba; Farrah Jabar, Children’s Hospital Research Institute of Manitoba; Kristine Kroeker, George and Fay Yee Centre for Healthcare Innovation; Tom Blydt-Hansen, University of British Columbia; Jon McGavock, Children’s Hospital Resarch Institute of Manitoba; Brandy Wicklow, Children’s Hospital Research Institute of Manitoba
Low vitamin D (25[OH]D) status is associated with an increased risk for several conditions including type 2 diabetes (T2D). The association between 25[OH]D sufficiency and T2D in youth is unknown.
A cross-sectional comparison of 25[OH]D status was performed among Indigenous youth with T2D (n=172) and overweight controls (n=53) within The Improving renal Complications in Adolescents with T2D through REsearch (iCARE) cohort. 25[OH]D status was classified as sufficient (≥50 nmol/L) or insufficient (< 50 nmol/L). Univariate and multivariate logistic regressions were performed.
The cohort had a mean age of 15.4±2.6 at baseline, 65.3% were female, and 72.9% were from rural communities. The majority of youth (79.1%) presented with insufficient 25[OH]D. Age, sex, glycemic control, obesity, and rurality were not associated with 25[OH]D status. In multivariate models, youth with T2D were 55% less likely to be sufficient in 25[OH]D (OR 0.45 [95% CI: 0.21, 0.96]). Data collected in the summer months (OR 3.04 [95% CI: 1.33, 6.96]) and self-reported 25[OH]D supplementation (OR 6.52 [ 95% CI: 2.30, 18.47]), were strong predictors of 25[OH]D status.
Youth with T2D and overweight controls have high rates of 25[OH]D insufficiency. Youth with T2D are less likely to be 25[OH]D sufficient compared to youth without T2D. Seasonality and 25[OH]D supplements strongly increase the odds of 25[OH]D sufficiency.