Abstracts

#14 Micronutrient deficiencies in children newly diagnosed with inflammatory bowel disease


Vini Deora, University of Manitoba; Nicole Aylward, Health Sciences Centre; AbdulRazzaq Sokoro, University of Manitoba; Wael El-Matary, University of Manitoba


Introduction

Inflammatory bowel disease (IBD) has been commonly linked with malnutrition. Children with untreated micronutrient deficiencies may have a complicated disease course. Screening and assessing children with IBD for under-nutrition is an essential component of routine clinical care.


Methods

Children (< 17 years) newly diagnosed with IBD had their serum vitamins and minerals measured at diagnosis. Clinical disease activity indices and inflammatory markers (C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR)) were also measured. Micronutrient deficiencies in children with Crohn’s disease were compared to those with ulcerative colitis (UC)


Results

142 children, [median age = 14 years, IQR = 12 – 15; 81 girls (57.04%); 69 with CD, 66 with UC and 7 with IBD unclassified (IBD-U)] with confirmed IBD were included. At diagnosis, vitamin D and serum iron were deficient in 104 (73.23%) and 74 (52.11%) children respectively. Serum zinc and copper were also insufficient in 24.6% and 17.6% respectively. Vitamin D deficiency was significantly more common children with CD (81.5%) vs those with UC (72.7%) (P= 0.04). Copper and zinc were also significantly lower in those with CD (33.3% and 34.8% respectively) vs UC (4.5% and 16.6%, P= 0.019 and 0.023 respectively). The mean serum level of vitamin D was significantly lower in children with CD (67.4+20.8 nmol/L) compared to those with UC (80.1+22.6 nmol/L) (P=0.03). Zinc mean level was also significantly lower in children with CD (9.6+0.6 umol/L) compared to those with UC (13.6+2.1umol/L) (P=0.04).


Conclusion

Micronutrient deficiencies are common in children newly diagnosed with IBD especially in those with Crohn’s disease.